Efficacy of liposomal amphotericin B combined with gamma interferon or granulocyte-macrophage colony-stimulating factor for treatment of systemic zygomycosis in mice.
نویسندگان
چکیده
Granulocyte-macrophage colony-stimulating factor enhanced the efficacy of liposomal amphotericin B (LAMB) in a murine model of disseminated infection by Rhizopus oryzae, significantly prolonging survival and reducing tissue burden. The use of gamma interferon (IFN-gamma) alone was ineffective, and IFN-gamma combined with LAMB did not improve the results obtained with LAMB alone.
منابع مشابه
Efficacy of liposomal amphotericin B combined with interferon- gamma or granulocyte-macrophage colony-stimulating factor for treatment of systemic zygomycosis in mice
50 words Text: 1014 words * Corresponding author. Mailing address: Unitat de Microbiologia, Facultat de Medicina, Universitat Rovira i Virgili. Carrer Sant Llorenç, 21.43201 Reus, Spain. Phone 977-759359. Fax: 977-759322. E-mail: [email protected] Copyright © 2009, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. Antimicrob. Agents Chemother. doi...
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 53 8 شماره
صفحات -
تاریخ انتشار 2009